Abstract
An improvement in myocardial longitudinal systolic velocities, assessed by pulsed-wave tissue Doppler imaging during low-dose dobutamine infusion, was observed at 6-month follow-up after 6 months of treatment with atorvastatin. Our findings indicate a favorable effect of atorvastatin on contractile reserve, possibly through an enhancement of flow-dependent coronary dilatation during stress.
Publication types
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Clinical Trial
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Randomized Controlled Trial
MeSH terms
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Aged
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Atorvastatin
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Blood Flow Velocity / drug effects
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Blood Pressure / drug effects
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Cardiotonic Agents
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Cholesterol, HDL / blood
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Cholesterol, HDL / drug effects
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Cholesterol, LDL / blood
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Cholesterol, LDL / drug effects
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Diastole / drug effects
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Diet, Fat-Restricted
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Dobutamine
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Echocardiography, Doppler / instrumentation
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Echocardiography, Doppler / methods*
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Female
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Follow-Up Studies
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Heart Rate / drug effects
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Heptanoic Acids / therapeutic use*
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Humans
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Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use*
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Hypercholesterolemia / blood
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Hypercholesterolemia / diagnostic imaging*
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Hypercholesterolemia / drug therapy*
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Hypercholesterolemia / physiopathology
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Male
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Middle Aged
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Myocardial Contraction / drug effects*
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Pyrroles / therapeutic use*
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Stroke Volume / drug effects
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Systole / drug effects
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Treatment Outcome
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Triglycerides / blood
Substances
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Cardiotonic Agents
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Cholesterol, HDL
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Cholesterol, LDL
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Heptanoic Acids
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Hydroxymethylglutaryl-CoA Reductase Inhibitors
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Pyrroles
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Triglycerides
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Dobutamine
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Atorvastatin