Displacement of primary sensorimotor cortex activation after subcortical stroke: a longitudinal PET study with clinical correlation

Neuroimage. 2003 Aug;19(4):1650-4. doi: 10.1016/s1053-8119(03)00205-2.

Abstract

Five patients with left striatocapsular infarction were studied twice with PET during auditory-cued right thumb-index tapping, around 2 months after stroke and again around 8 months after stroke. At PET1 and PET2, the ipsilesional primary sensorimotor (SM1) activation peak Talairach coordinates were compared to those from seven aged-matched healthy controls. At PET1, there was a significant posterior displacement of SM1 activation peak, which confirms a previous report and may represent unmasking/disinhibition of motor representations. Over time, there was no significant change in the coordinates, and no significant correlation between coordinate changes from PET1 to PET2 and concomitant motor recovery. The implications of posterior displacement of SM1 activation peak for recovery therefore remain elusive.

MeSH terms

  • Acoustic Stimulation
  • Brain Mapping
  • Corpus Striatum / diagnostic imaging*
  • Corpus Striatum / physiopathology
  • Dominance, Cerebral / physiology
  • Female
  • Follow-Up Studies
  • Hemiplegia / diagnostic imaging
  • Hemiplegia / physiopathology
  • Humans
  • Image Processing, Computer-Assisted / methods*
  • Internal Capsule / diagnostic imaging*
  • Internal Capsule / physiopathology
  • Male
  • Middle Aged
  • Motor Cortex / diagnostic imaging*
  • Motor Cortex / physiopathology
  • Psychomotor Performance / physiology*
  • Somatosensory Cortex / diagnostic imaging*
  • Somatosensory Cortex / physiopathology
  • Tomography, Emission-Computed / methods*