Effects of ultralow doses of antibodies to prostate-specific antigen on morphological and functional state of rat prostate

Bull Exp Biol Med. 2003 Jan:135 Suppl 7:91-3. doi: 10.1023/a:1024751301763.

Abstract

Morphological and morphometric assays showed that administration of antibodies to the prostate-specific antigen in ultralow doses for 1.5 months delayed the development of atrophic and sclerotic processes in rats with chronic aseptic prostatitis. The concentration of zinc ions playing an important role in binding of androgens increased in the prostate of rats receiving the preparation. Studies of copulatory behavior showed that male rats with chronic prostatitis receiving antibodies to the prostate-specific antigen displayed increased sexual activity compared to control and intact animals.

MeSH terms

  • Animals
  • Antibodies / pharmacology*
  • Dose-Response Relationship, Drug
  • Male
  • Prostate / drug effects*
  • Prostate / pathology
  • Prostate-Specific Antigen / immunology*
  • Prostatitis
  • Rats
  • Sexual Behavior, Animal / drug effects

Substances

  • Antibodies
  • Prostate-Specific Antigen