Characterization of the transit and transition times for a pathway unit of Michaelis-Menten mechanism

Biochim Biophys Acta. 2003 Sep 8;1623(1):6-12. doi: 10.1016/s0304-4165(03)00153-3.

Abstract

The transit time and a characteristic time constant for the transition time are formulated for a pathway unit of Michaelis-Menten mechanism in metabolic chains with mass-action-type dependence. The pathway unit in a chain is assigned to each metabolite and two consecutive Michaelis-Menten-type reactions associated with it. All the relevant functions such as control coefficients, elasticities and transit time for the pathway unit are expressed in terms of the flux J and other system parameters. The transition time is characterized by a time constant for a first-order system expressed as the derivative of the total concentration of the internal metabolite with respect to the flux J.

Publication types

  • Evaluation Study

MeSH terms

  • Computer Simulation
  • Feedback
  • Linear Models
  • Metabolism / physiology*
  • Models, Biological*
  • Models, Chemical*
  • Signal Transduction / physiology*
  • Time Factors