No association of germline alteration of MSR1 with prostate cancer risk

Liang Wang; Shannon K McDonnell; Julie M Cunningham; Scott Hebbring; Steven J Jacobsen; James R Cerhan; Susan L Slager; Michael L Blute; Daniel J Schaid; Stephen N Thibodeau

doi:10.1038/ng1239

No association of germline alteration of MSR1 with prostate cancer risk

Nat Genet. 2003 Oct;35(2):128-9. doi: 10.1038/ng1239. Epub 2003 Sep 7.

Authors

Liang Wang¹, Shannon K McDonnell, Julie M Cunningham, Scott Hebbring, Steven J Jacobsen, James R Cerhan, Susan L Slager, Michael L Blute, Daniel J Schaid, Stephen N Thibodeau

Affiliation

¹ Division of Experimental Pathology, Department of Laboratory Medicine and Pathology, 920 Hilton Building, Mayo Clinic and Foundation, Rochester, Minnesota, USA.

PMID: 12958598
DOI: 10.1038/ng1239

Abstract

The macrophage scavenger receptor 1 gene (MSR1) was recently identified as a candidate susceptibility gene for hereditary prostate cancer and as a risk factor for sporadic prostate cancer. To confirm these findings, we screened MSR1 for germline mutations among individuals with familial prostate cancer and tested gene variants for associations in both sporadic and familial prostate cancer. Our results do not support MSR1 as a risk factor for prostate cancer.

Publication types

Research Support, U.S. Gov't, P.H.S.

MeSH terms

Aged
Aged, 80 and over
Genetic Variation
Germ-Line Mutation*
Humans
Male
Middle Aged
Molecular Sequence Data
Prostate-Specific Antigen / blood
Prostatic Neoplasms / epidemiology
Prostatic Neoplasms / genetics*
Receptors, Immunologic / genetics*
Receptors, Scavenger
Reference Values
Risk Factors
Scavenger Receptors, Class A

Substances

MSR1 protein, human
Receptors, Immunologic
Receptors, Scavenger
Scavenger Receptors, Class A
Prostate-Specific Antigen

Associated data

RefSeq/NM_138715