Absence of an inhibitory effect of omeprazole and nizatidine on phenytoin disposition, a marker of CYP2C activity

K A Bachmann; T J Sullivan; L Jauregui; J H Reese; K Miller; L Levine

doi:10.1111/j.1365-2125.1993.tb00382.x

Absence of an inhibitory effect of omeprazole and nizatidine on phenytoin disposition, a marker of CYP2C activity

Br J Clin Pharmacol. 1993 Oct;36(4):380-2. doi: 10.1111/j.1365-2125.1993.tb00382.x.

Authors

K A Bachmann¹, T J Sullivan, L Jauregui, J H Reese, K Miller, L Levine

Affiliation

¹ The Center for Applied Pharmacology, The University of Toledo College of Pharmacy, Toledo, Ohio 43606, USA.

Abstract

The effects of omeprazole (40 mg orally per day) and nizatidine (300 mg orally per day) on the disposition of phenytoin (4.5 mg kg(-1) p.o. single dose) were studied in 18 healthy, young adult males. Total and unbound plasma concentrations of phenytoin were measured for 48 h after each dose of phenytoin. Neither treatment altered the disposition kinetics of phenytoin, the hydroxylation of which is mediated specifically by cytochromes P450 of the 2C subfamily.

Publication types

Comparative Study

MeSH terms

Adult
Analysis of Variance
Anti-Ulcer Agents / pharmacology*
Anticonvulsants / pharmacokinetics*
Cytochrome P-450 Enzyme System / metabolism*
Drug Interactions
Humans
Male
Nizatidine / administration & dosage
Nizatidine / pharmacology*
Omeprazole / administration & dosage
Omeprazole / pharmacology*
Phenytoin / blood
Phenytoin / pharmacokinetics*

Substances

Anti-Ulcer Agents
Anticonvulsants
cytochrome P-450 CYP2C subfamily
Phenytoin
Cytochrome P-450 Enzyme System
Omeprazole
Nizatidine