Drug-induced aminotransferase alterations during antiretroviral HIV post-exposure prophylaxis

AIDS. 2003 Sep 5;17(13):1988-90. doi: 10.1097/00002030-200309050-00020.

Abstract

In 655 individuals receiving HIV postexposure prophylaxis (PEP), drug-induced aminotransferase alterations were frequent and severe in the nevirapine-including regimen, rare and mild-to-moderate in other combinations, and always reversible. Grade 3-4 incidence in protease inhibitor or nevirapine PEP was 0.5 and 25.0 per 100 person-months, respectively. Apart from nevirapine, continuing PEP appears to be safe even in the case of aminotransferase alterations. The usefulness of routine monitoring of liver function during PEP could be re-considered.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Anti-HIV Agents / adverse effects*
  • Child
  • Child, Preschool
  • Female
  • HIV Infections / prevention & control*
  • Humans
  • Infectious Disease Transmission, Patient-to-Professional / prevention & control
  • Liver / drug effects*
  • Liver / physiopathology
  • Male
  • Middle Aged
  • Transaminases / blood
  • Transaminases / drug effects*

Substances

  • Anti-HIV Agents
  • Transaminases