Pediatric living donor liver transplantation

Transplant Proc. 2003 Aug;35(5):1808-9. doi: 10.1016/s0041-1345(03)00570-0.

Abstract

Aim: The aim of this study was to analyze the results of living donor in a pediatric liver transplantation program.

Patients: Twenty-six living donor liver transplantations were performed in children from 0.5 to 14.8 years of age. The main indication was biliary atresia (72%) followed by tumors (2 hepatoblastomas and 1 hepatocarcinoma). Left lateral segments were used in 23 (1 transformed into a monosegment), 1 left lobe was used in 1, and right lobes were used in 2. Arterial reconstruction employed saphenous venous grafts in the first 3 cases and end-to-end anastomoses with a microsurgical technique in the following 22 cases.

Results: There has been no major morbidity in the donors, with a median hospitalization of 6 days. Four grafts have been lost; 2 in the first 3 cases. In only 1 case, the graft loss was related to the procedure saphenous venous graft thrombosis). Early biliary complications were frequent (23%). Six month, 1 year, and 5 year graft and patient survival rates were 91%, 85%, and 85% and 100%, 96%, and 96%, respectively.

Conclusions: Living donor liver transplantation is an excellent option for transplantation in children.

MeSH terms

  • Adolescent
  • Child
  • Child, Preschool
  • Hepatectomy / methods
  • Humans
  • Infant
  • Liver Diseases / classification
  • Liver Diseases / surgery*
  • Liver Transplantation / physiology*
  • Living Donors / statistics & numerical data*
  • Postoperative Complications / epidemiology
  • Tissue and Organ Harvesting
  • Treatment Outcome