cis and trans regulation of tissue-specific transcription

J Cell Sci Suppl. 1992:16:21-31. doi: 10.1242/jcs.1992.supplement_16.4.

Abstract

Analysis of both the cis-regulatory sequences which control globin gene switching as well as the trans-acting factors which bind to these sequences to elicit a differential, developmentally regulated response has lent insight into the general mechanisms responsible for tissue-specific gene regulation. We show here that the chicken adult beta-globin gene promoter sequences are intimately involved in competitive interaction with the beta/epsilon-globin enhancer to regulate differentially epsilon- versus beta-globin gene transcription. Secondly, we show that the family of GATA transcription factors directs gene regulation in a variety of discrete cell types, and describe potential cellular target genes for each member of the GATA factor family, as well as potential mechanisms whereby multiple GATA factors expressed in a single cell might be used to elicit differential transcriptional activities.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Base Sequence
  • Binding Sites
  • Brain / embryology
  • Chick Embryo
  • DNA-Binding Proteins / genetics*
  • Erythroid-Specific DNA-Binding Factors
  • Gene Expression Regulation
  • Genes, Switch
  • Globins / genetics*
  • HIV / genetics*
  • Mice
  • Molecular Sequence Data
  • Transcription Factors / genetics*
  • Transcription, Genetic*

Substances

  • DNA-Binding Proteins
  • Erythroid-Specific DNA-Binding Factors
  • Transcription Factors
  • Globins