Atherosclerosis from a viewpoint of arterial wall cell function: relation to vitamin E

N Morisaki; K Yokote; Y Saito

doi:10.3177/jnsv.38.special_196

Atherosclerosis from a viewpoint of arterial wall cell function: relation to vitamin E

J Nutr Sci Vitaminol (Tokyo). 1992:Spec No:196-9. doi: 10.3177/jnsv.38.special_196.

Authors

N Morisaki¹, K Yokote, Y Saito

Affiliation

¹ Second Department of Internal Medicine, School of Medicine, Chiba University, Japan.

PMID: 1297739
DOI: 10.3177/jnsv.38.special_196

Abstract

Vitamin E affects many key events in atheromatous lesions. Inhibition of EC injury and platelet aggregation was already reported. Foam cell formation must be inhibited according to the data presented by us and other speakers. However, effects on cell proliferation of SMC are paradoxical. The in vivo effects will be dependent on the effective concentration of vitamin E in the loci.

Publication types

Comparative Study

MeSH terms

Animals
Arteries
Arteriosclerosis / metabolism
Arteriosclerosis / prevention & control*
Cell Adhesion / drug effects
Endothelium, Vascular / drug effects*
Endothelium, Vascular / enzymology
Endothelium, Vascular / metabolism
Free Radical Scavengers
Male
Monocytes / cytology
Muscle, Smooth, Vascular / cytology
Muscle, Smooth, Vascular / drug effects
Rats
Rats, Wistar
Sterol Esterase / drug effects
Vitamin E / pharmacology*
Vitamin E Deficiency / metabolism

Substances

Free Radical Scavengers
Vitamin E
Sterol Esterase