Double monoclonal cryoglobulinemia, glomerulonephritis and lymphoma

Nephron. 1992;62(4):459-64. doi: 10.1159/000187099.

Abstract

We present a case of monoclonal cryoglobulinemia with double monoclonal component IgA lambda-IgG lambda, without complement activation, membranoproliferative glomerulonephritis (MPGN) with deposits of IgA, IgG and lambda chains and lymphocytic IgA-lambda-chain-secreting lymphoma. This case emphasizes the possibility that double monoclonal cryoglobulins could behave differently compared to type I cryoglobulins, determining a MPGN-like type II cryoglobulins do, but without activating the complement cascade.

Publication types

  • Case Reports

MeSH terms

  • Antigens, CD / analysis
  • Antigens, Neoplasm / immunology
  • Clone Cells
  • Cryoglobulinemia / complications*
  • Gene Rearrangement, B-Lymphocyte
  • Glomerulonephritis, Membranoproliferative / etiology*
  • Glomerulonephritis, Membranoproliferative / immunology
  • Glomerulonephritis, Membranoproliferative / pathology
  • Humans
  • Lymphoma / complications*
  • Lymphoma / immunology
  • Lymphoma / pathology
  • Male
  • Middle Aged
  • Spleen / pathology

Substances

  • Antigens, CD
  • Antigens, Neoplasm