Abstract
The paper deals with results of complex treatment of 387 patients with stage III breast cancer assigned to either neoadjuvant chemotherapy and preoperative radiotherapy or radiation alone. A study of immediate and end results showed combination of the two modalities to be more effective than each method alone in terms of degree of regression of primary tumor and, particularly, lymph node metastases and duration of recurrence-free period.
Publication types
-
Clinical Trial
-
Comparative Study
-
English Abstract
-
Randomized Controlled Trial
MeSH terms
-
Adult
-
Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
-
Breast Neoplasms / mortality
-
Breast Neoplasms / therapy*
-
Chemotherapy, Adjuvant
-
Cyclophosphamide / administration & dosage
-
Female
-
Fluorouracil / administration & dosage
-
Humans
-
Lymphatic Metastasis
-
Mastectomy, Radical
-
Methotrexate / administration & dosage
-
Middle Aged
-
Neoplasm Recurrence, Local / epidemiology
-
Preoperative Care
-
Prospective Studies
-
Radiotherapy Dosage
-
Remission Induction
-
Thiotepa / administration & dosage
Substances
-
Cyclophosphamide
-
Thiotepa
-
Fluorouracil
-
Methotrexate