[Association studies in cancerology: the example of gene L-myc polymorphism associated with the incidence of pulmonary metastases in breast cancers]

Bull Cancer. 1992;79(12):1149-57.
[Article in French]

Abstract

Genes, which are implicated in the pathogenesis of human tumors, may demonstrate Restriction Fragment Length Polymorphism (RFLP). Population studies of such RFLP are of potential interest for a genetic analysis of cancer susceptibility. The initial data of Krontiris et al has shown a significant increase of rare c-Ha-ras-1 alleles in individuals with tumors. Since then, other significant associations have been found between other genes RFLPs and various tumors. In this paper, we report that L-myc RFLP may prove useful in identifying breast cancer patients at high risk of developing lung metastases.

Publication types

  • English Abstract

MeSH terms

  • Adult
  • Breast Neoplasms / genetics*
  • Disease Susceptibility
  • Female
  • Genes, myc*
  • Humans
  • Lung Neoplasms / genetics
  • Lung Neoplasms / secondary*
  • Middle Aged
  • Polymorphism, Genetic*
  • Retrospective Studies