Cathepsin G, a polymorphonuclear cell protease, affects the fibrinolytic system by releasing PAI-1 from endothelial cells and platelets

Ann N Y Acad Sci. 1992 Dec 4:667:286-8. doi: 10.1111/j.1749-6632.1992.tb51628.x.

Authors

G Pintucci¹, L Iacoviello, C Amore, V Evangelista, C Cerletti, M B Donati

Affiliation

¹ Istituto di Ricerche Farmacologiche Mario Negri, Consorzio Mario Negri Sud, Santa Maria Imbaro, Chieti, Italy.

PMID: 1309048
DOI: 10.1111/j.1749-6632.1992.tb51628.x

No abstract available

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Blood Platelets / drug effects
Blood Platelets / metabolism*
Cathepsin G
Cathepsins / blood
Cathepsins / pharmacology*
Cells, Cultured
Culture Media, Conditioned
Endothelium, Vascular / drug effects
Endothelium, Vascular / metabolism*
Extracellular Matrix / metabolism
Humans
Neutrophils / enzymology
Plasminogen Activator Inhibitor 1 / blood
Plasminogen Activator Inhibitor 1 / isolation & purification
Plasminogen Activator Inhibitor 1 / metabolism*
Serine Endopeptidases
Serpins / pharmacology
Umbilical Veins

Substances

Culture Media, Conditioned
Plasminogen Activator Inhibitor 1
Serpins
Cathepsins
Serine Endopeptidases
CTSG protein, human
Cathepsin G