Abstract
Transcriptionally active human papillomavirus type 6a (HPV-6a) DNA was detected in a lung carcinoma of a patient with recurrent laryngeal papillomatosis. The carcinoma contained episomal HPV-6a genomes that had a duplication of the upstream regulatory region, the late region and a portion of the early region. HPV-6a genomes found in benign laryngeal papillomas from the same patient did not contain this duplication. A role for the mutant molecules in the pathogenesis of the malignancy is suggested.
Publication types
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Case Reports
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adult
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Blotting, Northern
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Blotting, Southern
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Carcinoma, Squamous Cell / microbiology*
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DNA Restriction Enzymes
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DNA, Viral / analysis
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DNA, Viral / genetics
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Humans
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Laryngeal Neoplasms / microbiology*
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Lung Neoplasms / microbiology*
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Male
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Multigene Family
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Mutation
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Neoplasm Recurrence, Local / microbiology
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Papilloma / microbiology*
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Papillomaviridae / genetics*
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RNA, Viral / analysis
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Restriction Mapping
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Transcription, Genetic
Substances
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DNA, Viral
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RNA, Viral
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DNA Restriction Enzymes