AcrB multidrug efflux pump of Escherichia coli: composite substrate-binding cavity of exceptional flexibility generates its extremely wide substrate specificity

J Bacteriol. 2003 Oct;185(19):5657-64. doi: 10.1128/JB.185.19.5657-5664.2003.
No abstract available

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Anti-Bacterial Agents / metabolism*
  • Anti-Bacterial Agents / pharmacology
  • Binding Sites
  • Carrier Proteins / metabolism*
  • Drug Resistance, Multiple, Bacterial*
  • Escherichia coli / drug effects*
  • Escherichia coli / metabolism
  • Escherichia coli Proteins / metabolism*
  • Membrane Proteins / metabolism*
  • Models, Molecular
  • Multidrug Resistance-Associated Proteins
  • Substrate Specificity

Substances

  • AcrB protein, E coli
  • Anti-Bacterial Agents
  • Carrier Proteins
  • Escherichia coli Proteins
  • Membrane Proteins
  • Multidrug Resistance-Associated Proteins