Monoclonal antibody MON-114: detection of a marker for neuroendocrine differentiation in human lung cancer

H L van Duijnhoven; E H Moors; A Groeneveld; E D Timmer; L F de Leij; S S Wagenaar; J M Polak; W J van de Ven

doi:10.1016/0304-3835(92)90090-i

Monoclonal antibody MON-114: detection of a marker for neuroendocrine differentiation in human lung cancer

Cancer Lett. 1992 Mar 31;63(1):61-6. doi: 10.1016/0304-3835(92)90090-i.

Authors

H L van Duijnhoven¹, E H Moors, A Groeneveld, E D Timmer, L F de Leij, S S Wagenaar, J M Polak, W J van de Ven

Affiliation

¹ Department of Biochemistry, University of Nijmegen, The Netherlands.

PMID: 1313334
DOI: 10.1016/0304-3835(92)90090-i

Abstract

Mouse monoclonal antibody MON-114 was generated upon immunization with a human small cell lung carcinoma cell line GLC-19. Immunohistochemical analysis of normal tissues with MON-114 showed staining of the adrenal gland, brain and peripheral nerves. With respect to human lung carcinomas, 7 out of 8 small cell lung carcinomas were positively stained as well as 5 out of 5 carcinoid tumors, whereas only 4 out of 31 squamous cell carcinomas and 3 out of 19 adenocarcinomas were weakly stained. Furthermore, 1 large cell carcinoma was negative for MON-114 staining. Apparently, MON-114 stains cells of neuroendocrine differentiation.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antibodies, Monoclonal*
Antigens, Neoplasm / analysis*
Biomarkers, Tumor / analysis*
Carcinoma, Non-Small-Cell Lung / immunology*
Carcinoma, Small Cell / immunology*
Humans
Lung Neoplasms / immunology*
Mice
Mice, Inbred BALB C

Substances

Antibodies, Monoclonal
Antigens, Neoplasm
Biomarkers, Tumor