Uptake of 2-fluoro-2-deoxy-D-[U-14C]-glucose during chemotherapy in murine Lewis lung tumor

Int J Rad Appl Instrum B. 1992 Jan;19(1):55-63. doi: 10.1016/0883-2897(92)90185-2.

Abstract

Mice bearing intramuscular Lewis lung tumor were treated with BCNU and doxorubicin (ADM) to study chemotherapy-induced changes in the uptake of 2-fluoro-2-deoxy-[U-14C]glucose (FDG). A decreased FDG uptake, tumor regression and a diminished proportion of aneuploid versus diploid cells as evaluated by DNA flow cytometry were seen after treatment with BCNU but not with ADM; HPLC indicated that most of the 14C activity in tumors was from FDG6-phosphate. The results suggest that changes in FDG uptake reflect the effectiveness of antitumor therapy. FDG may be valuable in follow-up studies of cancer treatment.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenosine Triphosphate / metabolism
  • Animals
  • Carmustine / therapeutic use
  • Deoxyglucose / analogs & derivatives*
  • Deoxyglucose / metabolism
  • Doxorubicin / therapeutic use
  • Female
  • Flow Cytometry
  • Fluorodeoxyglucose F18
  • Glucose-6-Phosphatase / metabolism
  • Lung Neoplasms / diagnostic imaging*
  • Lung Neoplasms / drug therapy
  • Lung Neoplasms / metabolism
  • Mice
  • Mice, Inbred C57BL
  • Radionuclide Imaging

Substances

  • Fluorodeoxyglucose F18
  • Doxorubicin
  • Adenosine Triphosphate
  • Deoxyglucose
  • Glucose-6-Phosphatase
  • Carmustine