Abstract
The concentrations of doxycycline and 4-de-dimethylaminotetracycline required to inhibit 50% of collagenase activity were found to be 15 to 30 microM for human neutrophil and gingival crevicular fluid collagenases. Fibroblast collagenase was relatively resistant to inhibition by tetracyclines; the 50% inhibitory concentrations of doxycycline and 4-de-dimethylaminotetracycline were 280 and 510 microM, respectively.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Anti-Inflammatory Agents
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Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
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Fibroblasts / drug effects
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Fibroblasts / enzymology
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Humans
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Microbial Collagenase / antagonists & inhibitors*
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Microbial Collagenase / metabolism
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Neutrophils / drug effects
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Neutrophils / enzymology
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Tetracyclines / pharmacology*
Substances
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Anti-Inflammatory Agents
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Anti-Inflammatory Agents, Non-Steroidal
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Tetracyclines
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Microbial Collagenase