Delineation of the phagocyte NADPH oxidase through studies of chronic granulomatous diseases of childhood

Curr Opin Immunol. 1992 Feb;4(1):53-6. doi: 10.1016/0952-7915(92)90124-w.

Abstract

The phagocyte NADPH oxidase is a complex system consisting of membrane and cytosolic components that must assemble at the membrane for proper activation. Studies of patients with chronic granulomatous diseases of childhood have enabled the molecular characterization of these components, which has led to studies defining their interaction during NADPH complex assembly. Understanding NADPH oxidase assembly provides an opportunity to develop therapeutics for the regulation of this important reaction of inflammation.

Publication types

  • Review

MeSH terms

  • Child
  • Cytochrome b Group / genetics
  • Cytochrome b Group / metabolism
  • Cytosol / metabolism
  • Enzyme Induction
  • Granulomatous Disease, Chronic / enzymology*
  • Granulomatous Disease, Chronic / genetics
  • Granulomatous Disease, Chronic / pathology
  • Humans
  • Membrane Proteins / genetics
  • Membrane Proteins / metabolism
  • Multienzyme Complexes / genetics
  • Multienzyme Complexes / metabolism*
  • NADH, NADPH Oxidoreductases / genetics
  • NADH, NADPH Oxidoreductases / metabolism*
  • NADPH Oxidases
  • Neutrophils / enzymology
  • Phagocytes / enzymology*
  • Protein Processing, Post-Translational
  • Respiratory Burst
  • Superoxides / metabolism

Substances

  • Cytochrome b Group
  • Membrane Proteins
  • Multienzyme Complexes
  • Superoxides
  • cytochrome b558
  • NADH, NADPH Oxidoreductases
  • NADPH Oxidases