Abstract
A retrospective study determined that an epizootic of immune suppression and lymphoma in stump-tailed macaques (Macaca arctoides) that began in 1976 was associated with a horizontally spread lentivirus infection. This conclusion was based on serology, epidemiology, pathology, and virus isolation. The lesions found in the stump-tailed macaques were more compatible with lesions seen in SIV-infected rhesus than those seen in rhesus macaques infected with type D retroviruses. A lentivirus, isolated from a rhesus inoculated with lymph node homogenate from a stump-tailed macaque, was designed SIVstm and was pathogenic for rhesus macaques. The isolate was antigenically related to other SIVs as well as to HIV-1 and HIV-2. Two surviving stump-tailed macaques sent to another colony carried SIVstm latently for at least 7 years and disseminated it throughout that colony.
Publication types
-
Research Support, Non-U.S. Gov't
-
Research Support, U.S. Gov't, Non-P.H.S.
-
Research Support, U.S. Gov't, P.H.S.
MeSH terms
-
Animals
-
Antibodies, Viral / blood
-
Blotting, Western
-
Disease Outbreaks / veterinary*
-
HIV-1 / immunology
-
HIV-2 / immunology
-
Human T-lymphotropic virus 1 / immunology
-
Leukocytes, Mononuclear / microbiology
-
Leukocytes, Mononuclear / ultrastructure
-
Lymph Nodes / pathology
-
Lymphoma / complications
-
Lymphoma / veterinary*
-
Macaca*
-
Monkey Diseases / epidemiology
-
Monkey Diseases / microbiology*
-
Retrospective Studies
-
Retroviruses, Simian / immunology
-
Simian Acquired Immunodeficiency Syndrome / complications
-
Simian Acquired Immunodeficiency Syndrome / epidemiology
-
Simian Acquired Immunodeficiency Syndrome / microbiology*
-
Simian Immunodeficiency Virus / immunology
-
Simian Immunodeficiency Virus / isolation & purification
-
Simian Immunodeficiency Virus / ultrastructure
-
Virion / ultrastructure