Abstract
A new human gene encoding a putative receptor-type tyrosine kinase (RTK) was isolated by screening a placenta cDNA library with a mouse Flt3 probe. The deduced amino acid sequence of the intracellular region of the molecule showed that it was strongly related to the FLT1 and KDR/FLK1 gene products and to a lesser degree to members of the class III RTKs: FMS/CSF1R, PDGFRA/B, KIT, and FLT3. The gene was named FLT4. Cosmid clones of the mouse Flt4 gene were isolated. The human gene was localized to bands q34-q35 of chromosome 5, i.e., slightly telomeric to the CSF1R/PDGRFB tandem of genes, and the mouse homolog to chromosome 11, region A5-B1.
Publication types
-
Comparative Study
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Amino Acid Sequence
-
Animals
-
Chromosome Mapping
-
Chromosomes, Human, Pair 5*
-
Genes
-
Humans
-
Mice / genetics*
-
Molecular Sequence Data
-
Multigene Family
-
Nucleic Acid Hybridization
-
Protein-Tyrosine Kinases / genetics*
-
Receptors, Cell Surface / genetics*
-
Sequence Alignment
-
Sequence Homology, Nucleic Acid
-
Species Specificity
-
Vascular Endothelial Growth Factor Receptor-3
Substances
-
Receptors, Cell Surface
-
Protein-Tyrosine Kinases
-
Vascular Endothelial Growth Factor Receptor-3
Associated data
-
GENBANK/M74209
-
GENBANK/M74210
-
GENBANK/M74211
-
GENBANK/M74212
-
GENBANK/M74213
-
GENBANK/M74214
-
GENBANK/M74215
-
GENBANK/M76673
-
GENBANK/S41693
-
GENBANK/X69878