Abstract
T cell activation and T cell receptor variable (V) regions were studied with monoclonal antibodies in peripheral blood lymphocytes from 22 patients with measles. Increased (greater than 5%) activated T cells (HLA-DR+ CD3+ cells) were noted in 14 of the 22 patients. Elevations of V beta 5+ and V beta 8+ T cells were observed in two and four patients, respectively, and appeared to be associated with T cell activation. The duration of fever was significantly prolonged in those with increased (greater than 10%) activated T cells (p less than 0.01). These results suggest that T cell activation and the preferential expansion of V beta 8+ and V beta 5+ T cells are associated with the pathogenic process of measles.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adolescent
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Antibodies, Monoclonal / immunology
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Antigens, CD / analysis*
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Antigens, CD / immunology
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Antigens, Differentiation, T-Lymphocyte / genetics*
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Antigens, Differentiation, T-Lymphocyte / immunology
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Child
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Child, Preschool
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Female
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Gene Rearrangement, T-Lymphocyte / genetics*
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HLA-DR Antigens / analysis*
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HLA-DR Antigens / immunology
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Humans
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Infant
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Male
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Measles / genetics*
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Measles / immunology
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Receptors, Antigen, T-Cell / genetics*
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Receptors, Antigen, T-Cell / immunology
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Tumor Necrosis Factor Receptor Superfamily, Member 7
Substances
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Antibodies, Monoclonal
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Antigens, CD
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Antigens, Differentiation, T-Lymphocyte
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HLA-DR Antigens
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Receptors, Antigen, T-Cell
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Tumor Necrosis Factor Receptor Superfamily, Member 7