Abstract
Glutamate receptors are the principal excitatory neurotransmitter receptors in the central nervous system and are involved in a number of normal and pathological neuronal processes. Using subunit-specific antipeptide antibodies developed against the predicted amino acid sequences of several rat glutamate receptor cDNAs, we have identified these proteins in post-mortem human central nervous system tissue. Immunoblotting of dissected brain regions demonstrates that these receptor proteins are differentially distributed. The ability to identify these proteins in post-mortem human tissues should allow examination of the changes in levels of receptor subtypes that occur in a variety of neurological and psychiatric diseases.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adult
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Aged
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Aged, 80 and over
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Amino Acid Sequence
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Animals
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Antibody Specificity
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Central Nervous System / chemistry*
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Female
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Humans
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Immunoblotting
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Male
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Molecular Sequence Data
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Nerve Tissue Proteins / analysis
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Nerve Tissue Proteins / classification*
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Nerve Tissue Proteins / immunology
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Peptide Fragments / chemical synthesis
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Peptide Fragments / immunology
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Rats
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Receptors, AMPA
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Receptors, Glutamate
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Receptors, Neurotransmitter / analysis*
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Receptors, Neurotransmitter / classification*
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Receptors, Neurotransmitter / immunology
Substances
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Nerve Tissue Proteins
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Peptide Fragments
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Receptors, AMPA
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Receptors, Glutamate
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Receptors, Neurotransmitter