Abstract
The efficacy of synthetic immunoadjuvants and recombinant cytokines for the potentiation of host-resistance against virus infection was investigated using mouse models infected with Sendai virus and herpes simplex type 1 virus (HSV). The synthetic MDP derivative, MDP-Lys(L18), and recombinant cytokines, IL-1 beta, IFN-gamma, G-CSF and GM-CSF were shown to be effective for the stimulation of nonspecific protection against Sendai virus infection in mice. Both MDP-Lys(L18) and GM-CSF were effective for the protection against HSV infection in cyclophosphamide (CY)-treated mice. B30-MDP was suggested to be useful as an immunoadjuvant for the potentiation of antigenicity of recombinant or component vaccines.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Acetylmuramyl-Alanyl-Isoglutamine / analogs & derivatives
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Acetylmuramyl-Alanyl-Isoglutamine / chemistry
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Acetylmuramyl-Alanyl-Isoglutamine / pharmacology
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Adjuvants, Immunologic / pharmacology*
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Amino Acid Sequence
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Animals
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Cytokines / pharmacology*
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Herpes Simplex / immunology
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Herpes Simplex / prevention & control
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Male
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Mice
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Mice, Inbred BALB C
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Molecular Sequence Data
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Orthohantavirus / immunology
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Parainfluenza Virus 1, Human
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Paramyxoviridae Infections / immunology
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Paramyxoviridae Infections / prevention & control
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Viral Envelope Proteins / immunology
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Virus Diseases / immunology
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Virus Diseases / prevention & control*
Substances
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Adjuvants, Immunologic
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Cytokines
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Viral Envelope Proteins
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Acetylmuramyl-Alanyl-Isoglutamine
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romurtide