Hodgkin's disease and Epstein-Barr virus

Ann Oncol. 1992 Sep:3 Suppl 4:27-30. doi: 10.1093/annonc/3.suppl_4.s27.

Abstract

Seroepidemiological and molecular biological studies have established an association of Hodgkin's disease with Epstein-Barr virus (EBV). Recently, EBV genomes and gene products, most notably the latent membrane protein (LMP), have been detected in approximately 50% of the cases. The findings suggest that EBV may contribute to the pathoetiology of a sizable proportion of Hodgkin's disease cases.

Publication types

  • Review

MeSH terms

  • Antigens, CD / genetics
  • Antigens, Neoplasm / genetics
  • Antigens, Viral / genetics
  • Gene Expression Regulation, Neoplastic / genetics
  • Gene Expression Regulation, Viral / genetics
  • Genome, Viral
  • Herpesvirus 4, Human / genetics
  • Herpesvirus 4, Human / immunology
  • Herpesvirus 4, Human / pathogenicity*
  • Hodgkin Disease / etiology
  • Hodgkin Disease / genetics
  • Hodgkin Disease / microbiology*
  • Humans
  • Ki-1 Antigen
  • Lymphoma, Large B-Cell, Diffuse / genetics
  • Prognosis
  • Proteins / genetics
  • RNA-Binding Proteins*
  • Ribosomal Proteins*

Substances

  • Antigens, CD
  • Antigens, Neoplasm
  • Antigens, Viral
  • Ki-1 Antigen
  • Proteins
  • RNA-Binding Proteins
  • Ribosomal Proteins
  • RPL22 protein, human