Abstract
The sensitivity of in vivo MRS of the N-delta proton of the proximal histidine of deoxymyoglobin in human skeletal muscles is discussed. Longitudinal relaxation time T1 of this deoxymyoglobin signal was measured in cuffed human forearms at 1.5 T and found to be 9.9 ms. Deoxymyoglobin spectra can be obtained from a forearm in seconds. The detection sensitivity of deoxymyoglobin in fully ischemic skeletal muscles and that of 31P MRS of PCr in normal resting muscles are compared.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adult
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Animals
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Cattle
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Female
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Forearm / blood supply
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Histidine / metabolism*
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Humans
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Ischemia / metabolism
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Magnetic Resonance Spectroscopy* / methods
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Male
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Muscles / blood supply
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Muscles / metabolism*
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Myocardium / metabolism
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Myoglobin / analogs & derivatives*
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Myoglobin / metabolism
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Phosphocreatine / metabolism
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Phosphorus
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Protons
Substances
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Myoglobin
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Protons
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deoxymyoglobin
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Phosphocreatine
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Phosphorus
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Histidine