Ki-1-positive large-cell anaplastic lymphoma with protean manifestations including central nervous system involvement

Acta Haematol. 1992;88(2-3):147-50. doi: 10.1159/000204672.

Abstract

A 26-year-old female with Ki-1-positive large-cell anaplastic lymphoma is reported. The neoplastic cells were phenotypically and genotypically of T cell origin. Initially, neoplastic cells invaded the skin and lymph nodes, and then invaded the sternal and vertebral bones, ribs and the iliopsoas muscle. Central nervous system (CNS) involvement with paraplegia, large tumor mass formation in her breast and pleural infiltration ensued in succession. This case illustrates the protean manifestations of Ki-1-positive large cell anaplastic lymphoma complicated with CNS involvement.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antigens, CD / analysis*
  • Antigens, Neoplasm / analysis*
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Bone and Bones / pathology
  • Central Nervous System Diseases / etiology*
  • Cyclophosphamide / therapeutic use
  • Doxorubicin / therapeutic use
  • Female
  • Humans
  • Immunophenotyping
  • Ki-1 Antigen
  • Lymph Nodes / pathology
  • Lymphoma, Large B-Cell, Diffuse / complications
  • Lymphoma, Large B-Cell, Diffuse / drug therapy
  • Lymphoma, Large B-Cell, Diffuse / pathology*
  • Muscles / pathology
  • Prednisone / therapeutic use
  • Skin / pathology
  • T-Lymphocytes / pathology
  • Tomography, X-Ray Computed
  • Vincristine / therapeutic use

Substances

  • Antigens, CD
  • Antigens, Neoplasm
  • Ki-1 Antigen
  • Vincristine
  • Doxorubicin
  • Cyclophosphamide
  • Prednisone

Supplementary concepts

  • CHOP protocol