Dose-dependent vitamin D3, 25-hydroxyvitamin D3 and 1,25-dihydroxyvitamin D3-induced hypercalcemia and hyperphosphatemia, and the correlative changes in the activity of ultimobranchial and parathyroid glands of the toad, Bufo andersoni Boulenger

K Swarup; A K Pandey; N Hasan; V K Das

Dose-dependent vitamin D3, 25-hydroxyvitamin D3 and 1,25-dihydroxyvitamin D3-induced hypercalcemia and hyperphosphatemia, and the correlative changes in the activity of ultimobranchial and parathyroid glands of the toad, Bufo andersoni Boulenger

Biol Struct Morphog. 1992;4(4):174-81.

Authors

K Swarup¹, A K Pandey, N Hasan, V K Das

Affiliation

¹ The National Academy of Sciences, Allahabad, India.

PMID: 1339166

Abstract

Vitamin D3, 25(OH) vitamin D3 and 1,25 (OH)2D3 were administered daily to unfed male Bufo andersoni for 15 days which resulted in a significant hypercalcemia and hyperphosphatemia in a dose-dependent fashion. 1,25(OH)2D3 is more potent than the other metabolites. The treatment activated ultimobranchial gland but induced degenerative changes in parathyroid of the toads.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Bufonidae
Calcifediol / pharmacology*
Calcitriol / pharmacology*
Calcium / blood
Cholecalciferol / pharmacology*
Dose-Response Relationship, Drug
Hypercalcemia / blood
Hypercalcemia / chemically induced*
Male
Parathyroid Glands / drug effects
Parathyroid Glands / metabolism*
Phosphates / blood*
Ultimobranchial Body / drug effects
Ultimobranchial Body / metabolism*

Substances

Phosphates
Cholecalciferol
Calcitriol
Calcifediol
Calcium