The authors reported 23 cases of re-open heart surgery in 1473 patients with congenital heart disease treated surgically in the last ten years. The incidence was 1.6%. In 13 cases of the 23 re-open heart procedure was performed before closing the chest during the operation because of missed diagnosis in 5, incomplete correction of the anomaly in 5, and injure to important organ in 3. All of the 13 patients were recovered and discharged. Of the 23 cases re-open heart surgery was performed during the early postoperative period in 8 cases, including 4 cases of misdiagnosis, and 4 incomplete correction. 1 patient with VSD had still residual ventricular septal shunt post reintervention and died of circulatory failure. Re-open heart surgery was performed during the late postoperative period in 2 of the 23 cases. There was 1 missed diagnosis, and another incomplete correction. 1 patient died of massive bleeding during the reoperation. The anthers pointed out that accurate diagnosis and error-free operation is of most importance in avoiding re-open heart surgery. Through exploration to the heart after resuscitation during the operation and positive re-opening of the heart when necessary were emphasized. Indication of early and late postoperative re-open heart surgery and methods to prevent its complication were listed.