Abstract
In order to study how inflammatory cells including autoimmune lymphocytes interact with each other to develop collagen-induced arthritis (CIA), we injected monoclonal antibodies against mouse LFA-1 and ICAM-1 into DBA/1 mice immunized with type II collagen (CII). Both antibodies suppressed the development of CIA. These antibodies showed no effect on anti-CII antibody response, although they both significantly suppressed DTH response. It was suggested that anti-adhesion molecule antibodies suppress CIA mainly through their effect on cell-mediated immunity, without affecting humoral immunity under the conditions used.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antibodies, Monoclonal / administration & dosage*
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Arthritis, Rheumatoid / chemically induced
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Arthritis, Rheumatoid / drug therapy*
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Arthritis, Rheumatoid / pathology
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Cell Adhesion Molecules / immunology*
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Cells, Cultured / drug effects
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Collagen / administration & dosage
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Collagen / immunology*
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Disease Models, Animal
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Female
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Immunity, Cellular / drug effects
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Intercellular Adhesion Molecule-1
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Lymph Nodes / cytology
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Lymphocyte Function-Associated Antigen-1 / immunology*
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Mice
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Mice, Inbred DBA
Substances
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Antibodies, Monoclonal
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Cell Adhesion Molecules
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Lymphocyte Function-Associated Antigen-1
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Intercellular Adhesion Molecule-1
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Collagen