Cranial nerve involvement in childhood polyarteritis nodosa

Clin Neurol Neurosurg. 1992;94(1):11-3. doi: 10.1016/0303-8467(92)90111-f.

Abstract

Amongst a variety of neurological manifestations of childhood polyarteritis nodosa, cranial nerve involvement is unusual. We report 4 cases with cranial nerve palsies in a series of 36 biopsy-proven patients. Two cases presented with IIIrd nerve palsy alone, one with right IIIrd and left IVth nerve palsy, and one with peripheral VIIth nerve paresis. All 4 patients showed good response to prednisolone and cyclophosphamide treatment. Cranial nerve involvement in childhood polyarteritis nodosa seems not so rare when patients are followed on long term basis.

MeSH terms

  • Biopsy
  • Child
  • Child, Preschool
  • Cranial Nerve Diseases / drug therapy
  • Cranial Nerve Diseases / genetics
  • Cranial Nerve Diseases / pathology*
  • Cyclophosphamide / administration & dosage
  • Drug Therapy, Combination
  • Female
  • Humans
  • Male
  • Muscle, Smooth, Vascular / pathology
  • Muscles / blood supply
  • Neurologic Examination* / drug effects
  • Polyarteritis Nodosa / drug therapy
  • Polyarteritis Nodosa / genetics
  • Polyarteritis Nodosa / pathology*
  • Prednisolone / administration & dosage
  • Skin / blood supply

Substances

  • Cyclophosphamide
  • Prednisolone