Abstract
Carvedilol produced a dose-dependent inhibition of superoxide (O2-) release from human neutrophils (PMNs) (IC50 = 28 microM) and scavenged O2- generated during dihydroxyfumaric acid (DHF) autooxidation (IC50 = 41 microM). Other beta-blockers, such as celiprolol, labetalol and atenolol, or the antioxidant, 'lazaroid', U74500A had no effect on O2- either released from PMNs or generated during DHF autooxidation. Propranolol, at 0.3 mM, inhibited O2- release from PMNs (73%) but failed to scavenge O2- generated from DHF. The novel free radical-scavenging effect of carvedilol may contribute to the cardioprotective activity of the compound.
MeSH terms
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Adrenergic beta-Antagonists / pharmacology
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Adult
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Antihypertensive Agents / pharmacology
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Carbazoles / pharmacology*
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Carvedilol
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Free Radical Scavengers
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Fumarates / metabolism
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Humans
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In Vitro Techniques
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Lipid Peroxidation / drug effects
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Neutrophils / drug effects*
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Neutrophils / metabolism
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Propanolamines / pharmacology*
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Superoxides / metabolism*
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Tetradecanoylphorbol Acetate / pharmacology
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Vasodilator Agents / pharmacology
Substances
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Adrenergic beta-Antagonists
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Antihypertensive Agents
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Carbazoles
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Free Radical Scavengers
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Fumarates
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Propanolamines
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Vasodilator Agents
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Carvedilol
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Superoxides
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dihydroxyfumarate
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Tetradecanoylphorbol Acetate