Abstract
A single injection of monoclonal antibody to gamma interferon administered in conjunction with a live Candida albicans yeast cell vaccine resulted in the detection of nonprotective Th2 rather than protective Th1 responses and altered the early expression of interleukin 4 and gamma interferon mRNA in CD4+ cells.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antigens, Fungal / immunology
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CD4-Positive T-Lymphocytes / immunology*
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Candida albicans / immunology
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Candidiasis / immunology*
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Gene Expression
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Hypersensitivity, Delayed / immunology
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Immunity, Cellular
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Interferon-gamma / physiology*
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Interleukin-4 / genetics
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Mice
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RNA, Messenger / genetics
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T-Lymphocytes, Helper-Inducer / immunology*
Substances
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Antigens, Fungal
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RNA, Messenger
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Interleukin-4
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Interferon-gamma