No association between RFLPs at the porphobilinogen deaminase gene and schizophrenia

Hum Genet. 1992 Sep-Oct;90(1-2):131-2. doi: 10.1007/BF00210756.

Abstract

An association study of restriction fragment length polymorphisms (RFLPs) in the porphobilinogen deaminase (PBGD) gene and schizophrenia was conducted. RFLPs detected by MspI, PstI, ApaLI and BstNI in intron 1 of the gene were studied in 49 patients and 79 controls. There were no significant differences between the groups in allele frequencies, genotype counts or haplotype distribution.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Alleles
  • Female
  • Humans
  • Hydroxymethylbilane Synthase / genetics*
  • Introns / genetics
  • Male
  • Middle Aged
  • Polymorphism, Restriction Fragment Length*
  • Schizophrenia / enzymology*
  • Schizophrenia / genetics

Substances

  • Hydroxymethylbilane Synthase