Abstract
Disturbances in dopamine neurotransmission have been postulated to underlie schizophrenia. We report data from two independent studies of a BalI polymorphism in the dopamine D3 receptor gene in patients with schizophrenia. In both studies, more patients than controls were homozygous (p = 0.005, p = 0.008). When pooled data were analysed, this difference was highly significant (p = 0.0001) with a relative risk of schizophrenia in homozygotes of 2.61 (95% confidence intervals 1.60-4.26).
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Aged
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Alleles
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Base Sequence
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Chi-Square Distribution
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Chromosomes, Human, Pair 3*
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DNA / genetics
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Deoxyribonucleases, Type II Site-Specific
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Female
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Gene Frequency
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Homozygote
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Humans
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Male
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Middle Aged
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Molecular Sequence Data
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Polymorphism, Restriction Fragment Length
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Receptors, Dopamine / genetics*
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Receptors, Dopamine D2*
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Receptors, Dopamine D3
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Risk Factors
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Schizophrenia / genetics*
Substances
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DRD3 protein, human
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Receptors, Dopamine
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Receptors, Dopamine D2
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Receptors, Dopamine D3
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DNA
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Deoxyribonucleases, Type II Site-Specific
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TGGCCA-specific type II deoxyribonucleases