Simultaneous occurrence of monoclonal gammopathy and acute secondary leukemia with overexpression of P-glycoprotein

Tumori. 1992 Dec 31;78(6):403-6. doi: 10.1177/030089169207800613.

Abstract

A 52-year-old woman, previously treated with chemo- and radiotherapy for Hodgkin's disease, developed an acute non-lymphoid leukemia and, contemporarily, an IgG-kappa paraproteinemia. Cytogenetic analysis showed a major clone, representing 90% of observed metaphases, with monosomy of chromosomes 5 and 14. In addition, leukemic cells exhibited a high expression of the P-glycoprotein, a transmembrane glycoprotein involved in the multidrug-resistance mechanism. Possible explanations for this cluster of findings are provided.

Publication types

  • Case Reports

MeSH terms

  • ATP Binding Cassette Transporter, Subfamily B, Member 1
  • Adult
  • Combined Modality Therapy / adverse effects
  • Female
  • Hodgkin Disease / therapy*
  • Humans
  • Immunoglobulin kappa-Chains
  • Immunophenotyping
  • Leukemia, Myeloid, Acute / etiology*
  • Leukemia, Myeloid, Acute / metabolism
  • Membrane Glycoproteins / metabolism*
  • Middle Aged
  • Myelodysplastic Syndromes / complications*
  • Myelodysplastic Syndromes / etiology
  • Neoplasm Proteins / metabolism
  • Neoplasms, Second Primary / etiology*
  • Neoplasms, Second Primary / metabolism
  • Paraproteinemias / etiology*
  • Paraproteinemias / metabolism

Substances

  • ATP Binding Cassette Transporter, Subfamily B, Member 1
  • Immunoglobulin kappa-Chains
  • Membrane Glycoproteins
  • Neoplasm Proteins