The human pseudoautosomal GM-CSF receptor alpha subunit gene is autosomal in mouse

C M Disteche; C I Brannan; A Larsen; D A Adler; D F Schorderet; D Gearing; N G Copeland; N A Jenkins; L S Park

doi:10.1038/ng0892-333

The human pseudoautosomal GM-CSF receptor alpha subunit gene is autosomal in mouse

Nat Genet. 1992 Aug;1(5):333-6. doi: 10.1038/ng0892-333.

Authors

C M Disteche¹, C I Brannan, A Larsen, D A Adler, D F Schorderet, D Gearing, N G Copeland, N A Jenkins, L S Park

Affiliation

¹ Department of Pathology, University of Washington, Seattle 98195.

PMID: 1363815
DOI: 10.1038/ng0892-333

Abstract

The gene encoding the granulocyte macrophage colony stimulating factor receptor alpha subunit (CSF2RA) has previously been mapped to the pseudoautosomal region of the human sex chromosomes. In contrast, we report that the murine locus, Csf2ra, maps to an autosome in the laboratory mouse. By in situ hybridization and genetic mapping, Csf2ra maps at telomeric band D2 of mouse chromosome 19. This first instance of a pseudoautosomal locus in human being autosomal in mouse, indicates incomplete conservation between the human and mouse X chromosomes and suggests that the genetic content of the pseudoautosomal region may differ between species of eutherian mammals due to chromosomal rearrangements.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

MeSH terms

Animals
Chromosome Banding
Chromosome Mapping
Crosses, Genetic
Female
Granulocyte-Macrophage Colony-Stimulating Factor / genetics*
Humans
In Situ Hybridization
Macromolecular Substances
Male
Mice
Mice, Inbred C57BL
Muridae
Polymorphism, Restriction Fragment Length
Telomere
X Chromosome*

Substances

Macromolecular Substances
Granulocyte-Macrophage Colony-Stimulating Factor