[Adenylate cyclase system of the striatum in rats: regulatory properties and effect of gangliosides]

S A Plesneva; N N Nalivaeva; I A Zhuravin

[Adenylate cyclase system of the striatum in rats: regulatory properties and effect of gangliosides]

Ross Fiziol Zh Im I M Sechenova. 1997 Jan-Feb;83(1-2):90-5.

[Article in Russian]

Authors

S A Plesneva¹, N N Nalivaeva, I A Zhuravin

Affiliation

¹ Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Acad. Sci., 194223, M. Thoreza, 44, St. Petersburg, Russia.

PMID: 13676990

Abstract

Gpp[NH]p, forskolin, and NaF were found to activate the activity of adenylate cyclase in vitro in the membrane fraction of the striatum. Gangliosides decreased the level of basal activity of the striatal adenylate cyclase. Gangliosides were shown to modulate the activity of the enzyme through changes in its catalytic properties.

Publication types

English Abstract

MeSH terms

1-Methyl-3-isobutylxanthine / pharmacology
Adenylyl Cyclases / metabolism
Adenylyl Cyclases / physiology*
Animals
Colforsin / pharmacology
G(M1) Ganglioside / pharmacology
GTP-Binding Proteins / metabolism
Gangliosides / physiology*
Guanylyl Imidodiphosphate / pharmacology
Male
Neostriatum / drug effects
Neostriatum / enzymology*
Neostriatum / physiology*
Phosphodiesterase Inhibitors / pharmacology
Rats
Rats, Wistar
Sodium Fluoride / pharmacology

Substances

Gangliosides
Phosphodiesterase Inhibitors
Colforsin
Guanylyl Imidodiphosphate
G(M1) Ganglioside
Sodium Fluoride
GTP-Binding Proteins
Adenylyl Cyclases
1-Methyl-3-isobutylxanthine