We report two cases of non-MICS surgery successfully managed with Port-Access EndoCPB system. The first patient is a case of non-ruptured giant aneurysm of middle cerebral artery proposed for clipping procedure under hypothermic cardiopulmonary arrest. The second patient is a case of infectious pseudoaneurysm of the ascending aorta. We conclude that this system can be a powerful option of anesthetic strategy for the patients in need of cardiac arrest without having severe physical stress like sternotomy.