Synthesis and antimycobacterial activity of (3,4-diaryl-3H-thiazol-2-ylidene)-hydrazide derivatives

Maria Grazia Mamolo; Valeria Falagiani; Daniele Zampieri; Luciano Vio; Elena Banfi; Giuditta Scialino

doi:10.1016/S0014-827X(03)00103-4

Synthesis and antimycobacterial activity of (3,4-diaryl-3H-thiazol-2-ylidene)-hydrazide derivatives

Farmaco. 2003 Sep;58(9):631-7. doi: 10.1016/S0014-827X(03)00103-4.

Authors

Maria Grazia Mamolo¹, Valeria Falagiani, Daniele Zampieri, Luciano Vio, Elena Banfi, Giuditta Scialino

Affiliation

¹ Dipartimento di Scienze Farmaceutiche, Università di Trieste, Piazzale Europa 1, I-34127 Trieste, Italy. [email protected]

PMID: 13679155
DOI: 10.1016/S0014-827X(03)00103-4

Abstract

[5-(pyridin-2-yl)-1,3,4-thiadiazol-2-ylthio]acetic acid (3,4-diaryl-3H-thiazol-2-ylidene)-hydrazide derivatives were synthesized and tested for their in vitro antimycobacterial activity. Some compounds showed an interesting activity against a strain of Mycobacterium tuberculosis H(37)Rv and three clinical isolates of M. tuberculosis.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antitubercular Agents / chemical synthesis*
Antitubercular Agents / chemistry
Antitubercular Agents / pharmacology
Hydrazines / chemical synthesis*
Hydrazines / chemistry
Hydrazines / pharmacology
Mycobacterium tuberculosis / drug effects
Structure-Activity Relationship
Thiazoles / chemical synthesis*
Thiazoles / chemistry
Thiazoles / pharmacology

Substances

Antitubercular Agents
Hydrazines
Thiazoles