Abstract
Following the indications of previous work, 2-pyrrolidinone moiety of piracetam and piracetam-like compounds has been opened to the corresponding amide derivatives. As found previously in the case of 1,4-diazabicyclo[4.3.0]nonan-9-one compounds, the cognition-enhancing activity of 2-pyrrolidinone compounds is maintained in most cases, suggesting that this moiety is not crucial for activity.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Avoidance Learning / drug effects
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Drug Design
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Mice
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Nootropic Agents / chemical synthesis
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Nootropic Agents / chemistry*
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Nootropic Agents / pharmacology
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Piracetam / analogs & derivatives*
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Piracetam / chemical synthesis
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Piracetam / chemistry*
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Piracetam / pharmacology
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Pyrrolidinones / chemical synthesis
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Pyrrolidinones / chemistry*
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Pyrrolidinones / pharmacology
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Structure-Activity Relationship
Substances
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Nootropic Agents
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Pyrrolidinones
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2-pyrrolidone
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Piracetam