Abstract
Human lymphomas continue to represent a major challenge in oncology, and in particular occur at very high frequencies in AIDS patients. We report here the development of a CD30+ lymphoproliferative disease in mice lacking the proapoptotic transcription factor, interferon regulatory factor-1. These mice most closely represent a model of human anaplastic large-cell lymphoma (ALCL). This mouse model of lymphoma will likely be useful in understanding the development of ALCL and in understanding the development of other closely related CD30+ forms of lymphoma, such as CD30+ Hodgkin's disease and CD30+ cutaneous T-cell lymphoma. This mouse model will also be useful in testing therapies for different forms of CD30+ lymphoma, in particular anti-CD30-based therapies.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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DNA-Binding Proteins / genetics*
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Immunohistochemistry
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Interferon Regulatory Factor-1
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Ki-1 Antigen / metabolism*
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Lymph Nodes / metabolism
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Lymph Nodes / pathology
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Lymphatic Diseases / metabolism
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Lymphatic Diseases / pathology
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Lymphoma, Large-Cell, Anaplastic / metabolism*
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Lymphoma, Large-Cell, Anaplastic / pathology
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Lymphoma, Large-Cell, Anaplastic / ultrastructure
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Lymphoproliferative Disorders / genetics*
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Lymphoproliferative Disorders / metabolism*
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Lymphoproliferative Disorders / pathology
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Mice
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Mice, Knockout
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Phosphoproteins / genetics*
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Retinoblastoma Protein / genetics
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Time Factors
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Transcription Factors / genetics
Substances
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DNA-Binding Proteins
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Interferon Regulatory Factor-1
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Irf1 protein, mouse
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Ki-1 Antigen
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Phosphoproteins
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Retinoblastoma Protein
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Transcription Factors