Recombinant inbred mouse strains: models for disease study

M J Justice; N A Jenkins; N G Copeland

doi:10.1016/0167-7799(92)90193-y

Recombinant inbred mouse strains: models for disease study

Trends Biotechnol. 1992 Apr;10(4):120-6. doi: 10.1016/0167-7799(92)90193-y.

Authors

M J Justice¹, N A Jenkins, N G Copeland

Affiliation

¹ Mammalian Genetics Laboratory, NCI-Frederick Cancer Research and Development Center, MD 21702.

PMID: 1368097
DOI: 10.1016/0167-7799(92)90193-y

Abstract

Recombinant inbred (RI) strains of mice and the closely related recombinant congenic strains offer considerable promise for identifying and characterizing genes causally associated with many different diseases. Loci associated with diseases such as heart disease, autoimmune disease and leukemia have already been identified through the use of these unique strains.

Publication types

Research Support, U.S. Gov't, P.H.S.
Review

MeSH terms

Animals
Disease Models, Animal*
Humans
Mice
Mice, Inbred Strains / genetics*
Recombination, Genetic*

Abstract

Publication types

MeSH terms

Grants and funding