Characterization of two cDNAs encoding insulin-like growth factor 1 (IGF-1) in the human fetal brain

Brain Res Mol Brain Res. 1992 Jan;12(1-3):275-7. doi: 10.1016/0169-328x(92)90094-r.

Abstract

Insulin-like growth factor 1 (IGF-1) regulates growth of the brain. In order to characterize the variant IGF-1 present in human fetal brain we have determined the cDNA sequence for human fetal brain IGF-1. Using PCR to amplify cDNA obtained from isolated human fetal brain mRNA, two cDNA sequences encoding precursor proteins which correspond to IGF-1a and IGF-1b were obtained. This is the first characterisation of IGF-1 and its IGF-1a and IGF-1b precursors in the nervous system.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Base Sequence
  • Cerebral Cortex / embryology
  • Cerebral Cortex / physiology*
  • DNA / genetics*
  • Fetus
  • Gestational Age
  • Humans
  • Insulin-Like Growth Factor I / genetics*
  • Molecular Sequence Data
  • Poly A / genetics
  • Poly A / isolation & purification
  • RNA / genetics
  • RNA / isolation & purification
  • RNA, Messenger
  • Sequence Homology, Nucleic Acid

Substances

  • RNA, Messenger
  • Poly A
  • RNA
  • Insulin-Like Growth Factor I
  • DNA

Associated data

  • GENBANK/L01279
  • GENBANK/M87884
  • GENBANK/S72766
  • GENBANK/S72767
  • GENBANK/S72768
  • GENBANK/S72769
  • GENBANK/S72771
  • GENBANK/X56773
  • GENBANK/X56774
  • GENBANK/X63098