Divergent ileal IGF-I and IGFBP-3 gene expression after small bowel resection: a novel mechanism to amplify IGF action?

Mol Cell Endocrinol. 1992 Feb;83(2-3):R17-20. doi: 10.1016/0303-7207(92)90166-4.

Abstract

Changes in the levels of ileal insulin-like growth factor-I (IGF-I) and insulin-like growth factor binding protein-3 (IGFBP-3) mRNA in the rat following massive small bowel resection (MSBR) have been investigated with a sensitive S1 nuclease assay. IGF-I mRNA levels vary little over 7 days; in contrast IGFBP-3 mRNA levels decreased to one-third 7 h post-MSBR, and remained suppressed for the length of this study. We postulate that decreased ileal synthesis of IGFBP-3 enhances the ability of IGF-I to stimulate the adaptive response.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Carrier Proteins / biosynthesis
  • Carrier Proteins / genetics*
  • Female
  • Gene Expression*
  • Ileum / metabolism*
  • Insulin-Like Growth Factor Binding Proteins
  • Insulin-Like Growth Factor I / biosynthesis
  • Insulin-Like Growth Factor I / genetics*
  • Intestine, Small / surgery*
  • RNA, Messenger / analysis
  • RNA, Messenger / genetics*
  • Rats
  • Rats, Inbred Strains

Substances

  • Carrier Proteins
  • Insulin-Like Growth Factor Binding Proteins
  • RNA, Messenger
  • Insulin-Like Growth Factor I