Abstract
FR-111142 is a new angiogenesis inhibitor produced by a fungus Scolecobasidium arenarium F-2015. FR-111142 inhibited endothelial cell proliferation in vitro and angiogenesis in the growing chick chorioallantoic membrane model in vivo. Further, FR-111142 also suppressed the solid tumor growth in mice.
MeSH terms
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Allantois
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Animals
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Cell Survival / drug effects
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Chick Embryo
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Chorion
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Endothelium, Vascular / drug effects
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Epoxy Compounds / isolation & purification*
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Epoxy Compounds / pharmacology
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Female
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Fermentation
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Humans
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Mice
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Mice, Inbred BALB C
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Mitosporic Fungi / classification
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Mitosporic Fungi / metabolism
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Neoplasms, Experimental / drug therapy
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Neovascularization, Pathologic / prevention & control*
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Spiro Compounds / isolation & purification*
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Spiro Compounds / pharmacology
Substances
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Epoxy Compounds
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Spiro Compounds
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FR 111142