Abstract
Following primary infection, EBV retains a life-long latent association with B lymphocytes and a permissive association with stratified epithelium in the oropharynx. This review presents a model for the host-virus relationships in healthy virus carriers, a relationship which, if perturbed, may result in EBV-associated disease. Cytotoxic T cells that recognise virally-determined epitopes on infected cells are the major effector arm and control the persistant infection. A strategy for developing a vaccine to EBV is discussed.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Amino Acid Sequence
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Antigens, Viral / biosynthesis
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Antigens, Viral / immunology
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B-Lymphocytes / immunology
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B-Lymphocytes / microbiology
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Carrier State / immunology
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Carrier State / microbiology
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Epithelium / microbiology
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Epitopes / immunology
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Gene Expression Regulation, Viral
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Herpesviridae Infections / immunology*
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Herpesviridae Infections / microbiology
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Herpesvirus 4, Human / immunology*
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Herpesvirus 4, Human / physiology
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Humans
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Immune Tolerance
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Immunologic Surveillance*
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Infectious Mononucleosis / immunology
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Infectious Mononucleosis / microbiology
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Molecular Sequence Data
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Neoplasms / immunology
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Neoplasms / microbiology
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T-Lymphocytes, Cytotoxic / immunology
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Viral Proteins / biosynthesis
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Viral Proteins / immunology
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Viral Vaccines / immunology
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Virus Replication
Substances
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Antigens, Viral
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Epitopes
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Viral Proteins
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Viral Vaccines