Artiodactyl retroposons: association with microsatellites and use in SINEmorph detection by PCR

Nucleic Acids Res. 1992 Jun 25;20(12):2955-8. doi: 10.1093/nar/20.12.2955.

Abstract

During a search of polymorphic microsatellites for bovine genome mapping, we found that microsatellites often occur as tails of artiodactyl C-A retroposon elements. In this element, C (85bp) is a tRNA derivative, while A (117bp) is of unknown origin. The A element also occurs as dimer element with a connecting 27bp linker sequence comprising hexanucleotide CACTTT repeats. In 10 clones (45% of those selected deliberately for dinucleotide repeats), the microsatellite motif is associated with the C-A retroposon. In 50% of 44 database artiodactyl C-A sequences, the element also has a microsatellite tail. The microsatellite is usually a simple (CA)n repeat, but in some cases it is an apparent derivative of the linker sequence CACTTT. All but one of 33 database dimer elements have trinucleotide repeat tails (AGC)n, n = 1-9. Microsatellites, retroposons, and their truncated versions (C and/or A) often occur as clusters. We derived the consensus sequence (202bp) of the C-A element, and designed four primers for inter-SINE amplification with the aim of finding SINEmorph polymorphisms. The method is potentially powerful for rapidly producing polymorphic markers for artiodactyl genome mapping.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Base Sequence
  • Cattle
  • Cloning, Molecular
  • Consensus Sequence
  • DNA Transposable Elements / genetics*
  • DNA, Satellite / genetics*
  • Molecular Sequence Data
  • Polymerase Chain Reaction
  • RNA, Transfer / genetics*
  • RNA-Directed DNA Polymerase / metabolism

Substances

  • DNA Transposable Elements
  • DNA, Satellite
  • RNA, Transfer
  • RNA-Directed DNA Polymerase

Associated data

  • GENBANK/X65202
  • GENBANK/X65203
  • GENBANK/X65204
  • GENBANK/X65205
  • GENBANK/X65206
  • GENBANK/X65207
  • GENBANK/X65208
  • GENBANK/X65209
  • GENBANK/X65210
  • GENBANK/X65211
  • GENBANK/X65212
  • GENBANK/X65213
  • GENBANK/X65214
  • GENBANK/X65215
  • GENBANK/X65216
  • GENBANK/X65217