WS9326A, a novel tachykinin antagonist isolated from Streptomyces violaceusniger no. 9326. I. Taxonomy, fermentation, isolation, physico-chemical properties and biological activities

K Hayashi; M Hashimoto; N Shigematsu; M Nishikawa; M Ezaki; M Yamashita; S Kiyoto; M Okuhara; M Kohsaka; H Imanaka

doi:10.7164/antibiotics.45.1055

WS9326A, a novel tachykinin antagonist isolated from Streptomyces violaceusniger no. 9326. I. Taxonomy, fermentation, isolation, physico-chemical properties and biological activities

J Antibiot (Tokyo). 1992 Jul;45(7):1055-63. doi: 10.7164/antibiotics.45.1055.

Authors

K Hayashi¹, M Hashimoto, N Shigematsu, M Nishikawa, M Ezaki, M Yamashita, S Kiyoto, M Okuhara, M Kohsaka, H Imanaka

Affiliation

¹ Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., Ibaraki, Japan.

PMID: 1381343
DOI: 10.7164/antibiotics.45.1055

Abstract

Data from several studies suggest that tachykinins may play an important role in the pathophysiology of airway diseases, especially asthma. Our aim is to discover tachykinin antagonists which exhibit therapeutically useful anti-asthmatic activity. In our search for activities inhibiting the binding of [3H]substance P to guinea-pig lung membrane preparations, we have found that the fermentation product, WS9326A, isolated from Streptomyces violaceusniger, is a potent tachykinin receptor antagonist.

MeSH terms

Animals
Asthma / drug therapy
Fermentation
Guinea Pigs
In Vitro Techniques
Lactones / chemistry
Lactones / isolation & purification*
Lactones / pharmacology
Microscopy, Electron, Scanning
Peptides, Cyclic / chemistry
Peptides, Cyclic / isolation & purification*
Peptides, Cyclic / pharmacology
Streptomyces / chemistry
Substance P / antagonists & inhibitors
Substance P / metabolism
Tachykinins / antagonists & inhibitors*

Substances

Lactones
Peptides, Cyclic
Tachykinins
WS 9326A
FK 224
Substance P